Highly conserved serine residue 40 in HIV-1 p6 regulates capsid processing and virus core assembly
Abstract Background The HIV-1 p6 Gag protein regulates the final abscission step of nascent virions from the cell membrane by the action of two late assembly (L-) domains.Although p6 is Log Trolley located within one of the most polymorphic regions of the HIV-1 gag gene, the 52 amino acid peptide binds at least to two cellular budding factors (Tsg1